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Index | Go Back | Email This Information | Print Untitled Document Kidney Transplant

Kidney Transplant

Definition

A kidney transplant is a surgery to replace a diseased or damaged kidney with a donor kidney. It is done for patients with severe kidney problems. The donor may be a relative or friend. The donor can also be someone who has died and donated the organs.

Anatomy of the Kidney

Nucleus factsheet image

© 2009 Nucleus Medical Art, Inc.

Parts of the Body Involved

  • Kidney
  • Ureter (tube that brings urine from kidney to bladder)
  • Related blood vessels

Reasons for Procedure

A kidney transplant is done to treat irreversible, end-stage kidney diseases. The kidneys fail most often for the following reasons:

Risk Factors for Complications During the Procedure

  • Pre-existing medical conditions, especially certain heart, lung, and liver diseases
  • Autoimmune disease
  • Age extreme (young or old), of either the recipient or the donor
  • Difference in race between the recipient and donor
  • Prior blood transfusion
  • Prior failed transplant
  • Pregnancy
  • Conditions that will likely result in a recurrence of kidney failure in the new kidney
  • Cancer
  • Certain infections, such as osteomyelitis , tuberculosis , and hepatitis

What to Expect

Prior to Procedure

There is a shortage of donors. You may be on a transplant list for some time. You may need to carry a pager or cellular phone at all times so you can be reached if a donor kidney becomes available.

Your doctor will likely do the following:

  • Physical exam
  • Review of medications
  • Blood tests to include blood chemistries, liver function tests, bleeding profile, and infection testing
  • Electrocardiogram (ECG, EKG) ”a test that records the heart's activity by measuring electrical currents through the heart muscle
  • Chest x-ray
  • Extensive tissue typing

The procedure can be stressful. You may be asked to undergo psychological testing and counseling to prepare you.

The days leading up to your procedure:

  • Continue renal dialysis as directed by your doctor.
  • Your doctor may ask you to stop taking some of your current medications such as:
  • Take medications as directed. Do not take over-the-counter medications without checking with your doctor.
  • The night before, eat a light meal. Do not eat or drink anything after midnight.
  • Arrange for help at home after returning from the hospital.

Anesthesia

General anesthesia will be used for the surgery.

Description of the Procedure

The surgeon cuts into the lower abdomen. The donated kidney will be connected to your arteries, veins, and ureter. The diseased kidneys are usually left in place. The incision is closed. Your new kidney may start producing urine immediately or within a short time.

After Procedure

A catheter that is connected to a bag collecting urine will be left in your bladder.

You will be started on drugs to suppress your immune function. They will decrease the risk that your body will reject your new kidney.

How Long Will It Take?

The surgery typically takes about 3-6 hours.

Will It Hurt?

Anesthesia prevents pain during surgery. You may experience pain while recovering. You will receive pain medication to relieve this discomfort.

Possible Complications

  • Infection
  • Rejection of the new kidney
  • Urine leakage from the ureter
  • Heart problems from prior heart disease (such as heart attacks , heart failure , or heart rhythm problems)
  • Blood clot in the bladder or vein connected to the kidney
  • Postoperative diabetes
  • Gastrointestinal ulcers ”sores in the lining of the stomach or intestines
  • Phlebitis ”blood clots of a vein
  • Excessive swelling of your wound or legs
  • Damage to blood vessels or nerves
  • Cancer risk due to prolonged use of immunosuppression drugs
  • Urinary obstruction
  • Kidney stones

Average Hospital Stay

The typical recovery time in the hospital is 1-2 weeks. Most patients are in the intensive care unit for at least one day after surgery.

Postoperative Care

  • Take deep breaths and cough 10-20 times every hour. This will decrease the risk of pneumonia or fluid building up in your lungs.
  • Expect to get out of bed the day after surgery.
  • You may be given steroid medications. These will help to decrease inflammation in your new kidney.
  • You may be given diuretic medications. They will help rid your body of built up fluid.
  • Only take medications approved by your doctor.
  • Your new kidney may be monitored. Ultrasound examinations and nuclear medicine scans may be done.
  • You may be asked to weigh yourself, take your blood pressure daily, and to measure the amount of fluids you take in as well as the amount of urine you pass.
  • The amount of salt and protein you eat may be restricted.
  • You may be asked to avoid alcohol for at least a year.

Outcome

After a period of recovery, you will most likely be able to return to work and normal activities.

To reduce the chance that your body will reject the donor kidney, you will need to take immunosuppressive drugs for the rest of your life. These drugs can create a higher risk for a number of diseases including:

  • Recurrence of cancer
  • Liver disease if you have hepatitis C or B
  • Infections like tuberculosis or AIDS if you are infected before surgery
  • Kidney disease (in new kidney)
  • Weak bones

Additional drugs may be ordered to manage side effects..

More than 80% of transplanted kidneys from deceased donors remain working after one year. The success rate often improves with a kidney from a living donor. The kidney tissue in these cases more closely matches your tissue.

Call Your Doctor If Any of the Following Occurs

  • Signs of infection, including fever and chills
  • Redness, swelling, increasing pain, excessive bleeding, or discharge from the incision site
  • Cough, shortness of breath, chest pain, or severe nausea or vomiting
  • Pain, burning, urgency, frequency of urination, or persistent bleeding in the urine
  • Passing no or only small amounts of urine
  • Pain and/or swelling in your feet, calves, or legs, or sudden shortness of breath or chest pain
  • Coughing up blood
  • Sudden headache or feeling faint
  • Malaise
  • High blood pressure
  • Weight gain greater than three pounds in one day

RESOURCES:

National Kidney and Urologic Diseases Information Clearinghouse
http://kidney.niddk.nih.gov/

National Kidney Foundation
http://www.kidney.org/

CANADIAN RESOURCES:

The Kidney Foundation of Canada”Northern Alberta and the Territories Branch
http://www.kidney.ab.ca/

The Kidney Foundation of Canada”British Columbia Branch
http://www.kidney.bc.ca/

References:

Akbar SA, Jafri ZH, Amendola MA, et al. Complications of renal transplantation. RadioGraphics . 2005; 25: 1335-1356.

Cecil Textbook of Medicine . 21st ed. WB Saunders Co; 2000.

Halloran PF. Immunosuppressive drugs for kidney transplantation. NEJM . 2004; 351: 2715-2729.

Kaufman DB. Renal transplantation. eMedicine website. Available at: http://www.emedicine.com.

National Kidney and Urologic Diseases Information Clearinghouse website. Available at: http://kidney.niddk.nih.gov/index.htm.

Textbook of Surgery . 16th ed. WB Saunders Co; 2001.



Last reviewed December 2008 by Adrienne Carmack, MD

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

All EBSCO Publishing proprietary, consumer health and medical information found on this site is accredited by URAC. URAC's Health Web Site Accreditation Program requires compliance with 53 rigorous standards of quality and accountability, verified by independent audits.

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

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